Rule Set Detail

Density calculation using a distance map

File Information

Description

A distance map is a powerful layer to measure for every pixel in the object the minimal distance to the objects border. Here we use a distance map to compute distances between nuclei and estimate from there on the nuclei density.

After nuclei segmentation a distance map is calculated for the background area. This distance map allows us to measure the average distance of each nucleus to its neighbors. The a slightly averaged inverse of the nuclei-nuclei-distances is used to estimate and visualize the density.

Acknowledgements

Dr. Johannes Zimmermann for creative discussion and idea exchange.

Software Version
Definiens Developer XD - 1.5
Categories
Tissue
Files in Rule Set
  • nuclei_density_x.dcp(143 KB )
  • nuclei.jpg(320 KB )
  • result.jpg(250 KB )
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Tags
distance_map, object_based_region_growing
Views
850
Downloads
22
Created
01/19/2011

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